… disease. Second, we tested whether loss-of-function mutations in APOC3, which were …
, were also associated with reduced risks of ischemic vascular disease and ischemic heart …

… cardiovascular disease in the general population is unknown. We tested this hypothesis. …
with reduced risk of ischemic vascular disease (IVD) and ischemic heart disease (IHD) in …

… Objectives: Loss-of-function mutations in APOC3 are associated with substantial reductions
in risk of ischemic vascular disease(IVD). We tested to what extent this risk reduction was …

… risk of IVD and ischemic heart disease (IHD) associated with APOC3 loss-of-function mutations…
APOC3 inhibition is likely to reduce cardiovascular risk beyond LDL cholesterol lowering. …

… for clinical atherosclerotic cardiovascular disease (ASCVD) (2,3). Here, we address 2
questions related to mutations that reduce APOC3 function: 1) do these mutations also associate …

… and ApoC3 LOF mutations and incident cardiovascular disease (CVD) (defined as coronary
heart disease [CHD] plus ischemic stroke… Atherosclerosis Risk In Communities (ARIC) study. …

… that inhibition of APOC3 significantly reduces … that loss-of-function mutations in APOC3 are
associated with decreased triglyceride levels and a reduced risk of ischemic vascular disease …

… with an increased risk of coronary heart disease (CHD) and ischaemic vascular disease.
Now, in two … identify heterozygous mutations in the gene encoding apolipoprotein C-III (apo-CIII; …

… The SOFT coronary artery disease … artery bypass grafting, chronic ischemic heart disease
and angina. This meta-analysis includes data from up to 71,602 coronary artery disease cases …

… coronary artery disease and type 2 diabetes risk. Genetically lowered ANGPTL3 and
APOC3 also reduced coronary artery disease risk, but no impact on type 2 diabetes risk was …